Gram-scale preparation of dialkylideneacetones through Ca(OH)2-catalyzed Claisen-Schmidt condensation in dilute aqueous EtOH

[Display omitted] A practical synthetic method of dialkylideneacetones has been developed. Compared with known protocols, the method employed catalytic Ca(OH)2 as the cheap, mild base catalyst and dilute aqueous EtOH (20%, v/v) as the green and safe solvent. The products could be synthesized in gram...

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Bibliographic Details
Published in:Chinese chemical letters 2019-01, Vol.30 (1), p.263-265
Main Authors: Zhang, Hao, Han, Mengting, Yang, Chenggen, Yu, Lei, Xu, Qing
Format: Article
Language:English
Subjects:
Acetone
Aldehyde
Claisen-Schmidt condensation
Dialkylideneacetone
α,β-Unsaturated ketone
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Summary:[Display omitted] A practical synthetic method of dialkylideneacetones has been developed. Compared with known protocols, the method employed catalytic Ca(OH)2 as the cheap, mild base catalyst and dilute aqueous EtOH (20%, v/v) as the green and safe solvent. The products could be synthesized in gram-scale and isolated by a simple filtration. A synthetic method of dialkylideneacetones has been developed. Compared with known protocols, the method employed catalytic Ca(OH)2 as the cheap, mild base catalyst and dilute aqueous EtOH (20%, v/v) as the green and safe solvent. The procedure was easily operated: In most cases, the product could be isolated by a simple filtration, and purified by washing with water. This paper provided experimental details of the reactions, which could be applied in gram-scale synthesis and should be a very reliable and practical protocol to prepare these useful compounds in laboratory and at the industrial level.
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2018.01.035