External electrolyte-free electrochemical one-pot cascade synthesis of 4-thiocyanato-1H-pyrazoles

A practical synthetic method for 4-thiocyanato-1H-pyrazoles through the electrochemical cascade reaction of hydrazines, 1,3-diones and NH4SCN under metal-, chemical oxidant- and external electrolyte-free conditions was established. Importantly, both a gram-scale synthesis of 4-thiocyanato-1H-pyrazol...

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Bibliographic Details
Published in:Chinese chemical letters 2023-02, Vol.34 (2), p.107640, Article 107640
Main Authors: He, Wei-Bao, Zhao, Sai-Jie, Chen, Jing-Yang, Jiang, Jun, Chen, Xiang, Xu, Xinhua, He, Wei-Min
Format: Article
Language:English
Subjects:
Cascade reaction
Electrochemistry
Green chemistry
Multicomponent reaction
Thiocyanato
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Summary:A practical synthetic method for 4-thiocyanato-1H-pyrazoles through the electrochemical cascade reaction of hydrazines, 1,3-diones and NH4SCN under metal-, chemical oxidant- and external electrolyte-free conditions was established. Importantly, both a gram-scale synthesis of 4-thiocyanato-1H-pyrazoles and five one-pot sequential transformations starting from hydrazine were successfully accomplished. A practical synthetic method for 4-thiocyanato-1H-pyrazoles through the electrochemical cascade reaction of hydrazines, 1,3-diones and NH4SCN under metal-, chemical oxidant- and external electrolyte-free conditions was established. Importantly, both a gram-scale synthesis of 4-thiocyanato-1H-pyrazoles and five one-pot sequential transformations starting from hydrazine were successfully accomplished. [Display omitted]
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2022.06.063