Mitochondria-targeted nano-AIEgens as a powerful inducer for evoking immunogenic cell death

• Published in: Chinese chemical letters 2024-05, Vol.35 (5), p.108882, Article 108882
• Main Authors: Li, Kun-Heng, Zhao, Hong-Yang, Wang, Dan-Dan, Qi, Ming-Hui, Xu, Zi-Jian, Li, Jia-Mi, Zhang, Zhi-Li, Huang, Shi-Wen
• Format: Article
• Language: English
• Subjects: Aggregation induced emission; Immunogenic cell death; Mitochondria; Nanophotosensitizer; Photodynamic therapy; Reactive oxygen species
• ISSN: 1001-8417; 1878-5964
• DOI: 10.1016/j.cclet.2023.108882

AIEgens can serve as an effective platform for the construction of photosensitizer-based immunogenic cell death (ICD) inducers. To date, several mitochondria or endoplasmic reticulum (ER)-targeted aggregation-induced emission (AIE) molecules have been developed and have evoked massive ICD in cells. However, due to the complex physicochemical environment in cells, these small AIE molecules cannot maintain a stable aggregate state, which not only affects the fluorescence intensity of the photosensitizer but also decreases the generation of reactive oxygen species (ROS), and thus reducing the effect of the photosensitizer to elicit ICD. AIEgen-based nanomicelles, which maintain a stable micellar structure, can prevent defects of AIE molecules in photodynamic therapy (PDT) applications. Therefore, in this study, a mitochondria-targeted AIE nanophotosensitizer was synthesized and used as a highly potent ICD inducer for vaccine preparation and tumor prevention. In this study, we report a mitochondria-targeted AIE nanomicelle. AIE nanomicelle-based photodynamic generation of ROS in the mitochondria powerfully evokes immunogenic cell death to develop a vaccine for cancer prevention. [Display omitted]