A lipid droplets-targetable fluorescent probe for polarity detection in cells of iron death, inflammation and fatty liver tissue

Abnormal accumulation and metabolism of lipid droplets can lead to a variety of diseases. Polarity, a key parameter of the microenvironment, is closely associated with many diseases and dysfunctions in the body. It is important to elucidate the relationship between the physiological activity of lipi...

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Bibliographic Details
Published in:Chinese chemical letters 2024-06, Vol.35 (6), p.108912, Article 108912
Main Authors: Tian, Xing, Wu, Di, Wei, Wanheng, Dai, Guifu, Li, Zhanxian, Wang, Benhua, Yu, Mingming
Format: Article
Language:English
Subjects:
AIE
Fatty liver
Ferroptosis
Lipid droplets
Polarity
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Summary:Abnormal accumulation and metabolism of lipid droplets can lead to a variety of diseases. Polarity, a key parameter of the microenvironment, is closely associated with many diseases and dysfunctions in the body. It is important to elucidate the relationship between the physiological activity of lipid droplets (LDs) and the polarity of the microenvironment. In this work, based on push-pull mechanism, a fluorescent probe (E)-3-(5-(4-(diphenylamino)phenyl)thiophen-2-yl)-1-(2-hydroxyphenyl)prop‑2-en-1-one (PPTH) with aggregation-induced emission (AIE) properties for the detection of polarity changes in cells was synthesized. PPTH not only visualize intracellular polarity fluctuation of iron death and inflammation but also distinguish between normal and fatty liver tissue. Based on push-pull mechanism, a fluorescent probe (E)-3-(5-(4-(diphenylamino)phenyl)thiophen-2-yl)-1-(2-hydroxyphenyl)prop‑2-en-1-one (PPTH) with aggregation-induced emission (AIE) properties for polarity detection in cells of iron death, inflammation and fatty liver tissue was synthesized. PPTH can effectively localize lipid droplets, monitor intracellular polarity fluctuation and distinguish between normal and fatty liver tissue. [Display omitted]
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2023.108912