Luminescent terphen[3]arene sulfate-activated FRET assemblies for cell imaging

Multicharged supramolecular assemblies based on luminescent macrocycle play an important role in extending their optical properties and functions. Herein, we reported macrocyclic supramolecular assemblies based on luminescent terphen[3]arene sulfate (TP[3]AS) and tetraphenylethylene pyridinium (TPE-...

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Bibliographic Details
Published in:Chinese chemical letters 2024-09, Vol.35 (9), p.109666, Article 109666
Main Authors: Liu, Zhixue, Chen, Haiqi, Guo, Lijuan, Sun, Xinyao, Zhang, Zhi-Yuan, Chen, Junyi, Dong, Ming, Li, Chunju
Format: Article
Language:English
Subjects:
Cell imaging
Förster resonance energy transfer
Luminescent macrocycle
Multicharged assembly
Multivalent interactions
Terphenarene sulfate
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Summary:Multicharged supramolecular assemblies based on luminescent macrocycle play an important role in extending their optical properties and functions. Herein, we reported macrocyclic supramolecular assemblies based on luminescent terphen[3]arene sulfate (TP[3]AS) and tetraphenylethylene pyridinium (TPE-4Py) through electrostatic interactions, host-guest encapsulation and π-π stacking interactions. Förster resonance energy transfer (FRET) process from TP[3]AS to TPE-4Py was achieved with the energy transfer efficiency of 99.9%, accompanied by TPE-4Py fluorescence emission bathochromic shifted of 15 nm and enhanced by 1.68 times in PBS solution. In contrast, other non-luminescent sulfato-β-cyclodextrin and sulfobutylether-β-cyclodextrin only can enhance the fluorescence intensity of TPE-4Py without bathochromic shift. Due to the strong fluorescence and good stability of TPE-4Py@TP[3]AS, it can be used for optical imaging in living cells, which provided an effective approach for the construction of assembling-confined luminescent biomaterials. Luminescent macrocyclic terphen[3]arene sulfate (TP[3]AS) assembly with tetraphenylethylene pyridinium (TPE-4Py) through multivalent interactions not only achieved an effective Förster resonance energy transfer (FRET) process with energy transfer efficiency of 99.9%, but also realized TPE-4Py fluorescence emission bathochromic shift of 15 nm and enhancement by 1.68 times in PBS solution, exhibiting superior optical imaging capabilities in living cells. [Display omitted]
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2024.109666