Polyphenol-rich Fraction of Terminalia catappa Prevents Chronic Lead Acetate Induced Oxidative Stress and Cardiorenal Toxicities in Rats

Lead (Pb), a naturally occurring environmental contaminant, has been implicated in several pathological conditions of the cardiovascular and renal systems. The study was designed to evaluate the modulatory roles of the polyphenol-rich fraction of Terminalia catappa on chronic lead acetate-induced ca...

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Bibliographic Details
Published in:Clinical complementary medicine and pharmacology 2022-06, Vol.2 (2), p.100032, Article 100032
Main Authors: Ajibade, Temitayo, Adebayo, Adedeji, Oyagbemi, Ademola, Omobowale, Temidayo
Format: Article
Language:English
Subjects:
Antioxidant
Cardio-renal
Lead acetate
Phytotherapy
Rat
Terminalia catappa
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Summary:Lead (Pb), a naturally occurring environmental contaminant, has been implicated in several pathological conditions of the cardiovascular and renal systems. The study was designed to evaluate the modulatory roles of the polyphenol-rich fraction of Terminalia catappa on chronic lead acetate-induced cardiovascular and renal toxicities in rats. Thirty-six rats were randomly selected and divided into six groups of six rats each. Pb toxicity was induced by the administration of 100 mg/L Pb in drinking water for 12 weeks in groups B-F. Groups A and B were left untreated; groups C and D were treated with polyphenol-rich fraction of Terminalia catappa [PRFTC (100 and 200 mg/kg b.w.)]; vitamin E (50 mg/kg b.w.) and lisinopril (10 mg/kg b.w.) were administered to groups E and F, respectively. Exposure of rats to Pb induced significantly elevated (P 
ISSN:2772-3712
2772-3712
DOI:10.1016/j.ccmp.2022.100032