RETRACTED: Downregulation of p53-inducible microRNAs 192, 194, and 215 Impairs the p53/MDM2 Autoregulatory Loop in Multiple Myeloma Development

• Published in: Cancer cell 2010-10, Vol.18 (4), p.367-381
• Main Authors: Pichiorri, Flavia, Suh, Sung-Suk, Rocci, Alberto, De Luca, Luciana, Taccioli, Cristian, Santhanam, Ramasamy, Zhou, Wenchao, Benson, Don M., Hofmainster, Craig, Alder, Hansjuerg, Garofalo, Michela, Di Leva, Gianpiero, Volinia, Stefano, Lin, Huey-Jen, Perrotti, Danilo, Kuehl, Michael, Aqeilan, Rami I., Palumbo, Antonio, Croce, Carlo M.
• Format: Article
• Language: English
• Subjects: Animals; Cell Cycle - drug effects; Cell Line, Tumor; Cell Movement - drug effects; Cell Proliferation - drug effects; Chromosomes, Human, Pair 11 - genetics; DNA Methylation - drug effects; DNA Methylation - genetics; Down-Regulation - drug effects; Down-Regulation - genetics; Gene Expression Regulation, Neoplastic - drug effects; Homeostasis - drug effects; Homeostasis - genetics; Humans; Insulin-Like Growth Factor I - metabolism; Mice; MicroRNAs - genetics; Models, Biological; Multiple Myeloma - genetics; Multiple Myeloma - pathology; Mutagens - toxicity; Neoplasm Invasiveness; Precancerous Conditions - genetics; Precancerous Conditions - pathology; Promoter Regions, Genetic - genetics; Proto-Oncogene Proteins c-mdm2 - genetics; Proto-Oncogene Proteins c-mdm2 - metabolism; Receptor, IGF Type 1 - metabolism; RNA, Messenger - genetics; RNA, Messenger - metabolism; Tumor Suppressor Protein p53 - metabolism
• ISSN: 1535-6108; 1878-3686
• DOI: 10.1016/j.ccr.2010.09.005

This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the editors. This article was published on October 19, 2010, and Figures 4A and 7A were later corrected on August 8, 2016. In January 2021, The Ohio State University notified the Cancer Cell editors that an internal investigation concluded that Figures 1E, 4A, 4D, 5A, and 7A were falsified and that part of Figure 1E of the article is the same as part of Figure 1F in the correction of another article (Pichiorri et al., 2017, J. Exp. Med., 214, 1557, https://doi.org/10.1084/jem.2012095001172017c) and recommended retraction of the article. The editors no longer have confidence in the validity of the data and are retracting the article. S.-S. S. agrees with the retraction, and F.P., C.H., A.P., and C.M.C. disagree with the retraction; all other authors couldn't be reached or didn't respond.