Texaphyrin: From molecule to nanoparticle

•Texaphyrins, pentaaza Schiff base expanded porphyrins with a 5-coordination sphere.•Strong influence of metal cation on metallotexaphyrin functionality.•Clinical evaluations of texaphyrins eluded appreciable efficacy and utility.•The combination of texaphyrins with nanotechnology can serve to solve...

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Bibliographic Details
Published in:Coordination chemistry reviews 2019-01, Vol.379, p.133-146
Main Authors: Keca, Joseph M., Zheng, Gang
Format: Article
Language:English
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Summary:•Texaphyrins, pentaaza Schiff base expanded porphyrins with a 5-coordination sphere.•Strong influence of metal cation on metallotexaphyrin functionality.•Clinical evaluations of texaphyrins eluded appreciable efficacy and utility.•The combination of texaphyrins with nanotechnology can serve to solve the pitfalls. In the present review, we present the history and future of texaphyrins, pentaaza Schiff base macrocycles with an expanded 5-coordination sphere, possessing chelation prowess of 24 different stable 1:1 complexes. Intrinsically unique photophysical and magnetic properties of metallotexaphyrins have enabled a broad spectrum of applications, resulting in multiple clinical phase trial evaluations of these compounds. The combination of texaphyrins with nanotechnology underscores the promising future of these materials, which aims to resolve inherent limitations of molecular counterparts in a nanovehicle.
ISSN:0010-8545
1873-3840
DOI:10.1016/j.ccr.2017.08.026