Activity-based fluorescence probes for pathophysiological peroxynitrite fluxes

• Published in: Coordination chemistry reviews 2022-03, Vol.454, p.214356, Article 214356
• Main Authors: Mao, Zhiqiang, Xiong, Jianhua, Wang, Pengzhan, An, Jusung, Zhang, Fan, Liu, Zhihong, Seung Kim, Jong
• Format: Article
• Language: English
• Subjects: Activity-based sensing; Fluorescent probe; Inflammation; Peroxynitrite; Tumor
• ISSN: 0010-8545; 1873-3840
• DOI: 10.1016/j.ccr.2021.214356

[Display omitted] •ONOO− is implicated in inflammations, tumors, liver injuries, and brain diseases.•Fluorescence imaging of pathophysiological ONOO− by activity-based sensing (ABS) probes are summarized.•ABS probes would boost more new insights about the roles of ROS in diseases.•The review provides a general guide to designing ROS/RNS probes in disease diagnosis. Peroxynitrite (ONOO−), one of the reactive oxygen and nitrogen species (RONS), is famous for its potent oxidation and nitration capabilities and plays crucial roles in various pathological conditions. Given the similar chemical properties of various RONS (e.g. short half-life time, ultralow content, and mutual interconversion), specific detecting of ONOO− over other RONS remains a challenging mission in the complex physiological environment, primarily ONOO− related pathological processes. To decipher the intricate associations, molecular imaging assisted by activity-based sensing (ABS) fluorescent probes has become the “state-of-art” method due to its superiorities, including susceptible and selective detection results, non-invasive and real-time visualization. This review focuses on the research of ABS fluorescent probes that revealed the vital roles of ONOO− in various diseases, such as inflammations, tumors, liver injuries, and brain diseases. Finally, we discuss the bottlenecks and future developing trends for ABS probes which will boost ABS probes’ applications in chemistry, biology, and pharmacology.