Tumor vasculature associated nanomedicine strategies

The tumor vasculature plays a crucial role in promoting tumor growth and metastasis, showcasing heterogeneity in terms of tissue composition, functionality, and structural characteristics. The main limitation of traditional anti-tumor therapy arises from the disordered occlusion and structural abnor...

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Bibliographic Details
Published in:Coordination chemistry reviews 2024-12, Vol.521, p.216189, Article 216189
Main Authors: Wang, Xiaorui, Song, Xuejiao, Wei, Qinglin, Wang, Wenjun, Xu, Huae, Dong, Xiaochen
Format: Article
Language:English
Subjects:
Antiangiogenic
Nanomedicine
Tumor embolization
Tumor vascular disruption
Tumor vasculature normalization
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Summary:The tumor vasculature plays a crucial role in promoting tumor growth and metastasis, showcasing heterogeneity in terms of tissue composition, functionality, and structural characteristics. The main limitation of traditional anti-tumor therapy arises from the disordered occlusion and structural abnormalities present within the vascular network of the tumor, which create a bottleneck effect. Hence, the advancement of nanomedicine techniques targeting the tumor vascular system offer a fresh and exciting direction for the treatment of cancer. In this review, the intricate dynamics between the tumor microenvironment (TME) and the tumor vasculature is explored with a focus on the functions of hypoxia, increased angiogenic factor expression, and inflammatory cytokines in the TME. Furthermore, this review provides a comprehensive analysis of various vascular-related treatments, delving into the mechanisms behind each approach. Specifically, the recent advancements in nanomedicines targeting for therapeutic strategies are highlighted, namely anti-tumor angiogenic therapy, tumor vascular structure disruption, tumor vasculature normalization, and embolization therapy. Lastly, an overview of the challenges and prospects associated with tumor vascular therapy using nanomedicines is presented. •The correlation between tumor vasculature and tumor microenvironment was explored.•Elucidate the mechanism of nanomedicines acting on tumor vasculature.•The synergistic mechanisms and antitumor effect of co-vascular therapy were analyzed.•The barriers and potentials of nanomedicine in tumor vessel therapy were summarized.
ISSN:0010-8545
DOI:10.1016/j.ccr.2024.216189