An efficient continuous-flow synthesis and evaluation of antimicrobial activity of novel 1,2,3-Triazole-Furan hybrid chalcone derivatives

An efficient continuous-flow synthetic protocol developed for novel 1,2,3-triazole-furan hybrid chalcone derivatives by Claisen-Schmidt condensation of 1-phenyl-1H-1,2,3-triazole-4-carbaldehydes with 2-acetylfuran using KOH as base catalyst. The newly synthesized chalcones characterized by using dif...

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Bibliographic Details
Published in:Chemical Data Collections 2020-08, Vol.28, p.100457, Article 100457
Main Authors: Kumar, Kodide Santhosh, Siddaiah, V., Lilakar, J.D., Ganesh, Arram
Format: Article
Language:English
Subjects:
1,2,3-triazole
Antimicrobial activity
Claisen-schmidt condensation
Flow chemistry
Furan
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Summary:An efficient continuous-flow synthetic protocol developed for novel 1,2,3-triazole-furan hybrid chalcone derivatives by Claisen-Schmidt condensation of 1-phenyl-1H-1,2,3-triazole-4-carbaldehydes with 2-acetylfuran using KOH as base catalyst. The newly synthesized chalcones characterized by using different spectral data such as IR, 1HNMR, 13CNMR, mass spectrometry and elemental analysis. The antimicrobial screening of the chalcone derivatives results showed that the compounds 3 h and 3i have most promising activity. [Display omitted]
ISSN:2405-8300
2405-8300
DOI:10.1016/j.cdc.2020.100457