UV screening, swelling and in-vitro cytotoxicity study of novel chitosan/poly (1-vinylpyrrolidone-co-vinyl acetate) blend films

• Published in: Chemical Data Collections 2021-06, Vol.33, p.100684, Article 100684
• Main Authors: Gasti, Tilak, Hiremani, Vishram D., Sataraddi, Sarala P., Vanjeri, Vinayak N., Goudar, Naganagouda, Masti, Saraswati P., Chougale, Ravindra B., Malabadi, Ravindra B.
• Format: Article
• Language: English
• Subjects: Chitosan; Cytotoxicity; PVP-co-VAc; Swelling; UV screening
• ISSN: 2405-8300; 2405-8300
• DOI: 10.1016/j.cdc.2021.100684

•Novel CS/PVP-co-VAc blend films were prepared via solvent casting technique.•CSP blend films showed enhanced UV screening property.•Swelling index of CSP films increased about ≈91.5% than pure CS.•In-vitro cytotoxicity of the CSP blend films had MMT (%) assay > 90% against HEK296 cell line. The novel Chitosan (CS)/ Poly (1-vinylpyrrolidone-co-vinyl acetate) (PVP-co-VAc) blend films (CSP) were prepared by solvent casting method. The film properties were studied by FT-IR spectroscopy, UV–-visible spectroscopy, Thermal analysis, and Water contact angle. The light transmittance and UV screening rate of CSP films remarkably increased (85.22%) than CS film. The CSP blend films attained high thermal stability as well as glass transition temperature (Tg) than CS. The surface roughness and hydrophilicity of the CSP films significantly enhanced by the influence of PVP-co-VAc that leads to increase in the swelling property of the CSP films about ≈91% than CS film. In addition, in-vitro cytotoxicity of the CSP films showed cell viability (%) > 90% against human embryonic kidney cell line. These results suggest that the prepared CSP blend films have the potential to be implemented in the field of UV screening barriers, drug delivery and wound dressing material. [Display omitted]