Synthesis and biological evaluation of 1,2,4-oxadiazole incorporated 1,2,3-triazole-pyrazole derivatives as anticancer agents

A library of 1,2,4-oxadiazole incorporated 1,2,3-triazole-pyrazoles (10a-j) were designed, synthesized and tested for their anticancer activities towards human cancer cell lines such as PC3, DU-145 (prostate cancer), A549 (lung cancer) and MCF-7 (breast cancer) by using MTT method with etoposide as...

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Bibliographic Details
Published in:Chemical Data Collections 2021-08, Vol.34, p.100735, Article 100735
Main Authors: G, Mohan, Sridhar, Gattu, Laxminarayana, E., Chary, M. Thirumala
Format: Article
Language:English
Subjects:
1,2,4-oxadiazole and anticancer activity
Ataluren
Crizotinib
Pyrazole
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Summary:A library of 1,2,4-oxadiazole incorporated 1,2,3-triazole-pyrazoles (10a-j) were designed, synthesized and tested for their anticancer activities towards human cancer cell lines such as PC3, DU-145 (prostate cancer), A549 (lung cancer) and MCF-7 (breast cancer) by using MTT method with etoposide as standard drug. Among them, compound 10b showed most promising anticancer activity against PC3, A549, MCF-7, and DU-145 cell lines with IC50 values of 0.01±0.008 µM; 0.45±0.023 µM; 0.081±0.0012 µM and 1.77±0.33 µM. [Display omitted]
ISSN:2405-8300
2405-8300
DOI:10.1016/j.cdc.2021.100735