Synthesis and biological evaluation of amide derivatives of benzoxazole linked Imidazo[2,1-b][1,3,4]thiadiazole as antiproliferative agents

A new series of various substituted aryl and hetero aryl amide derivatives of benzoxazole linked imidazo[2,1-b][1,3,4]thiadiazole (11a-j) were synthesized and their structures confirmed by spectral data. These newly synthesized compounds (11a-j) were evaluated for their anticancer profile towards hu...

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Bibliographic Details
Published in:Chemical Data Collections 2022-06, Vol.39, p.100856, Article 100856
Main Authors: Bhogireddy, Danayya Nayudu, Surapureddi, Sri Ramakrishna, Palle, Sadanandam, Tadiboina, Bhaskara Rao
Format: Article
Language:English
Subjects:
5-Formyl-6-phenylimidazo-[2,1-b][1,3,4]thiadiazole sulfonamide
Benoxaprofen
Benzoxazole and anticancer
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Summary:A new series of various substituted aryl and hetero aryl amide derivatives of benzoxazole linked imidazo[2,1-b][1,3,4]thiadiazole (11a-j) were synthesized and their structures confirmed by spectral data. These newly synthesized compounds (11a-j) were evaluated for their anticancer profile towards human prostate cancer (PC3 and DU-145), lung cancer (A549) and breast cancer (MCF-7) cell lines by used of MTT assay and etoposide was chosen as positive control. Most of the derivatives displayed good to moderate antiproliferative activities with respective cell lines. Among the evaluated compounds, four compounds (11a, 11b, 11c and 11d) demonstrated more potent anticancer activity. Particularly, compound 11a showed strongest activity as etoposide. [Display omitted]
ISSN:2405-8300
2405-8300
DOI:10.1016/j.cdc.2022.100856