Case–control study of oropharyngeal cancer

Background: In order to test some hypotheses of risk factors for oropharyngeal cancer (neoplasm of base of tongue, palate and tonsils) matched case–control study was conducted in Belgrade, Serbia and Montenegro, during the period 1998–2000. Methods: Study comprised 100 incidence cases with oropharyn...

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Bibliographic Details
Published in:Cancer detection and prevention 2006-01, Vol.30 (2), p.152-157
Main Authors: Vlajinac, Hristina D., Marinkovic, Jelena M., Sipetic, Sandra B., Andrejic, Dragoslava M., Adanja, Benko J., Stosic-Divjak, Svetlana L.
Format: Article
Language:English
Subjects:
Adult
Age
Aged
Air Pollutants, Occupational - adverse effects
Alcohol
Alcohol Drinking - adverse effects
Beer
Cancer
Carcinogens, Environmental - adverse effects
Case-Control Studies
Case–control study
Cigarettes
Confidence intervals
Dust
Epidemiology
Family history
Family medical history
Female
Herpes simplex virus (HSV)
Human papilloma virus (HPV)
Humans
Infections
Liquor
Logistic Models
Logistics
Male
Mens health
Middle Aged
Mortality
Occupational
Oropharyngeal cancer
Oropharyngeal Neoplasms - epidemiology
Oropharyngeal Neoplasms - etiology
Risk Factors
Smoking
Smoking - adverse effects
Studies
Throat surgery
Tumors
Womens health
Wood
Wood dust
Yugoslavia - epidemiology
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Summary:Background: In order to test some hypotheses of risk factors for oropharyngeal cancer (neoplasm of base of tongue, palate and tonsils) matched case–control study was conducted in Belgrade, Serbia and Montenegro, during the period 1998–2000. Methods: Study comprised 100 incidence cases with oropharyngeal cancer and 100 controls with some non-malignant diseases of head and neck. Results: According to multivariate analysis, ever smoking, interaction between smoking and alcohol consumption, and occupational exposure to wood dust were found to be independent risk factors for oropharyngeal cancer (odds ratio—OR = 5.10 95% confidence intervals—95% CI = 1.70–15.27, OR = 2.61 95% CI = 1.54–4.41, and OR = 4.16 95% CI = 1.45–11.91, respectively). Conclusion: The results of the present study are in line with other authors , findings showing that smoking and alcohol consumption are the main risk factors for oropharyngeal cancer. The effect of occupational exposure to wood dust warrants further investigation.
ISSN:0361-090X
1877-7821
1873-443X
1877-783X
DOI:10.1016/j.cdp.2006.02.001