Synthesis of Pluronic® F127-poly (methyl vinyl ether-alt-maleic acid) copolymer and production of its micelles for doxorubicin delivery in breast cancer

[Display omitted] •Pluronic grafted poly (methyl vinyl ether-maleic acid) copolymer was synthesized successfully.•Produced micelle showed proper particles size, CMC, loading and release efficiency.•Pluronic grafted poly (methyl vinyl ether-maleic acid) micelle showed pH-dependent drug release.•Doxor...

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Bibliographic Details
Published in:Chemical engineering journal (Lausanne, Switzerland : 1996) Switzerland : 1996), 2014-03, Vol.240, p.133-146
Main Authors: Varshosaz, J., Hassanzadeh, F., Sadeghi-aliabadi, H., Larian, Z., Rostami, M.
Format: Article
Language:English
Subjects:
Breast cancer
Copolymer
Doxorubicin
Micelle
Pluronic® F127
Poly (methyl vinyl ether-alt-maleic acid)
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Summary:[Display omitted] •Pluronic grafted poly (methyl vinyl ether-maleic acid) copolymer was synthesized successfully.•Produced micelle showed proper particles size, CMC, loading and release efficiency.•Pluronic grafted poly (methyl vinyl ether-maleic acid) micelle showed pH-dependent drug release.•Doxorubicin loaded in micelles caused more cytotoxicity (p
ISSN:1385-8947
1873-3212
DOI:10.1016/j.cej.2013.11.086