Large-scale synthesis of dihydrostreptomycin via hydrogenation of streptomycin in a membrane dispersion microreactor

•A novel method for the preparation of dihydrostreptomycin.•Conversion rate (99.5%) of streptomycin were reached in 3 min.•The difference between the microreactor and the traditional stirring tank was investigated.•The effect of the pH of the aqueous solution and other factors was investigated. In t...

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Bibliographic Details
Published in:Chemical engineering journal (Lausanne, Switzerland : 1996) Switzerland : 1996), 2018-02, Vol.334, p.2250-2254
Main Authors: Xia, Siting, Ding, Xifeng, Wang, Yujun, Luo, Guangsheng, Wu, Zhongtao, Cheng, Yaofeng, Hao, Baoyuan
Format: Article
Language:English
Subjects:
Dihydrostreptomycin
Hydrogenation
Mass transfer
Membrane dispersion microreactor
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Summary:•A novel method for the preparation of dihydrostreptomycin.•Conversion rate (99.5%) of streptomycin were reached in 3 min.•The difference between the microreactor and the traditional stirring tank was investigated.•The effect of the pH of the aqueous solution and other factors was investigated. In this work, a membrane dispersion microreactor was applied for the hydrogenation of streptomycin (STR) to produce dihydrostreptomycin (DHS). The reductant was dispersed into the continuous phase containing STR, leading to a significant increase in the mass-transfer specific surface area, and the conversion rate of STR reached 99.81 wt% within 3 min. In contrast, in stirred tanks, the conversion rate of STR only reached 99.5% in 30 min. Moreover, the minimum amount of KBH4 used in the membrane dispersion microreactor was about 35.71% lower than that in traditional tanks, when achieving the same conversion rate at about 99.5%.
ISSN:1385-8947
1873-3212
DOI:10.1016/j.cej.2017.11.134