Degradable conductive injectable hydrogels as novel antibacterial, anti-oxidant wound dressings for wound healing

• Published in: Chemical engineering journal (Lausanne, Switzerland : 1996) Switzerland : 1996), 2019-04, Vol.362, p.548-560
• Main Authors: Qu, Jin, Zhao, Xin, Liang, Yongping, Xu, Yameng, Ma, Peter X., Guo, Baolin
• Format: Article
• Language: English
• Subjects: Antibacterial activity; Antioxidant property; Conducting polymers; Electroactive hydrogel; Injectable hydrogel; Wound dressing
• ISSN: 1385-8947; 1873-3212
• DOI: 10.1016/j.cej.2019.01.028

[Display omitted] •A kind of multi-functional injectable conductive hydrogel dressing was designed.•The hydrogel exhibited good electroactive property and free radical scavenging capacity.•By encapsulating antibiotic amoxicillin, hydrogel showed effective antibacterial property.•Hydrogel with aniline tetramer (AT) addition significantly accelerated wound healing rate in a full-thickness skin defect. Besides preventing wound infection, novel wound dressing materials are highly expected to exhibit the extraordinary wound repair and skin regeneration advantage. Herein, we designed a kind of multi-functional injectable hydrogel dressing, integrating the conductivity, desirable antioxidant ability and antibacterial property to meet increasing requirements of skin damage. By mixing the biocompatible polymer N-carboxyethyl chitosan (CEC) and oxidized hyaluronic acid-graft-aniline tetramer (OHA-AT) polymer under physiological conditions, the conductive anti-oxidant hydrogels OHA-AT/CEC were fabricated. The hydrogels exhibited stable rheological property, high swelling ratio, suitable gelation time, good in vitro biodegradation property, electroactive property and free radical scavenging capacity. With the antibiotic amoxicillin addition, the hydrogel showed good antibacterial property to effectively prevent the wound infection. In vivo experiments indicated that hydrogel with AT addition (OHA-AT/CEC hydrogels) significantly accelerated wound healing rate with higher granulation tissue thickness, collagen disposition and more angiogenesis in a full-thickness skin defect model. In one word, the present approach can shed new light on designing of electroactive injectable hydrogels with promising applications in wound dressing.