An injectable hydrogel based on phenylboronic acid hyperbranched macromer encapsulating gold nanorods and Astragaloside IV nanodrug for myocardial infarction

•A new way to efficiently utilize the Chinese traditional medicine was explored.•This new drug delivery system can achieve drug targeting and sustained release.•The system provide an alternative way to effectively treat MI.•Effects of the system on improving cardiac function in MI rats was elucidate...

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Bibliographic Details
Published in:Chemical engineering journal (Lausanne, Switzerland : 1996) Switzerland : 1996), 2021-06, Vol.413, p.127423, Article 127423
Main Authors: Chen, Jingrui, Han, Xiaoxu, Deng, Jie, Zhang, Jing, Li, Lan, Ni, Jingyu, Huang, Yuting, Xie, Xianhua, Chen, Si, Ke, Linnan, Gao, Xiumei, Wang, Wei, Fan, Guanwei
Format: Article
Language:English
Subjects:
Astragaloside IV
Conductivity
Drug delivery systems
Injectable hydrogel
Myocardial infarction
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Summary:•A new way to efficiently utilize the Chinese traditional medicine was explored.•This new drug delivery system can achieve drug targeting and sustained release.•The system provide an alternative way to effectively treat MI.•Effects of the system on improving cardiac function in MI rats was elucidated. Cardiac tissue engineering has a great applicable prospect in the treatment of heart disease. The hyperbranched polymer polyethylene glycol diacrylate/4-vinyl phenylboronic acid (PEGDA-PBA) and thiol hyaluronic acid (HA-SH) form an in situ hydrogel that adsorbs AST NPs to achieve drug targeting and sustained release. In addition, the composite hydrogel has certain properties of electrical stimulation through doping of gold nanorods (GNRs). In vitro studies indicated that this gel system exhibited electrical conductivity similar as a natural heart, and has a good efficacy to release drug. Our present study found that the injectable conductive hydrogel loaded with Astragaloside IV nanoparticles (AST NPs) effectively inhibited left ventricular remodeling and myocardial dysfunction after myocardial infarction (MI) in rats. HB (PEG-PBA)/HA-SH/AST NPs/GNRs also upregulated infarct margin angiogenesis, reduced cell apoptosis, and increased an expression of Connexm43 (Cx43). Thus, this bioactive injectable conductive hydrogel may provide an effective therapeutic strategy for the treatment of MI.
ISSN:1385-8947
1873-3212
DOI:10.1016/j.cej.2020.127423