TICT-based turn-on deep-red fluorescent probe for endoplasmic reticulum targeted detection of serum albumin in kidney diseases

• Published in: Chemical engineering journal (Lausanne, Switzerland : 1996) Switzerland : 1996), 2023-05, Vol.464, p.142551, Article 142551
• Main Authors: Wang, Hongwei, Wang, Jinling, Ma, Gang, Zhou, Jianjian, Du, Longjie, Wu, Hanli, Zhang, Xiaomeng, He, Yongrui, Zhou, Jin
• Format: Article
• Language: English
• Subjects: Acute kidney injury (AKI); Chronic kidney disease (CKD); Fluorescent probe; Serum albumin
• ISSN: 1385-8947; 1873-3212
• DOI: 10.1016/j.cej.2023.142551

[Display omitted] •An endoplasmic reticulum-targeted fluorescent probe was devised to sense serum albumin.•The probe has been used in cell models of ischemia–reperfusion and nephrotoxic drugs-induced AKI successfully.•The probe can quantitatively detect serum albumin in urine samples of CKD rats and human beings. Serum albumin is an important biomarker of kidney disease, and the rapid and accurate detection of serum albumin is of great significance for clinical diseases, for example, acute kidney injury, chronic kidney disease, and so forth. We designed and synthesized a TICT-based deep-red fluorescent probe that targets endoplasmic reticulum and interacts with serum albumin with good sensing performance. The probe has been successfully applied to the imaging of serum albumin in live cells models of ischemia–reperfusion and nephrotoxic drugs-induced treatment, and more importantly, the probe can quantitatively detect serum albumin in urine samples of rats and human beings with chronic kidney disease by fluorescence method, which is expected to be a promising tool for the diagnosis of kidney disease.