Multiple bonds crosslinked antibacterial, conductive and antioxidant hydrogel adhesives with high stretchability and rapid self-healing for MRSA infected motion skin wound healing

• Published in: Chemical engineering journal (Lausanne, Switzerland : 1996) Switzerland : 1996), 2023-07, Vol.468, p.143362, Article 143362
• Main Authors: Wang, Wenzhi, Jia, Ben, Xu, Huiru, Li, Zhenlong, Qiao, Lipeng, Zhao, Yueran, Huang, Heyuan, Zhao, Xin, Guo, Baolin
• Format: Article
• Language: English
• Subjects: High conductivity; Infected motion skin wound healing; Multiple bioactivity; Self-healing hydrogel adhesive; Stretchable hydrogel
• ISSN: 1385-8947
• DOI: 10.1016/j.cej.2023.143362

[Display omitted] •A novel hydrogel dressing was prepared by multiple bonds.•The hydrogel dressing had good conductivity, antibacterial and anti-oxidation properties.•The hydrogel dressing exhibited self-healing properties and super stretch properties.•The hydrogel dressing with strain sensing could promote motion wound healing process. Drug-resistant bacterial infection and low healing efficiency in motion skin wounds impose significant new requirements on design of wound dressings in terms of flexibility, self-healing, antibacterial activity, and multiple biological activities, and dressings mismatching the mechanical and biochemical properties of the wound will severely limit wound recovery. Herein, we developed a multiple bonds crosslinked antibacterial, conductive and antioxidant hydrogel adhesive with high stretchability and rapid self-healing for infected motion wound healing. The hydrogel is fabricated by one-pot photo-crosslinking the mixture of poly(glycerol sebacate)-co-poly(ethylene glycol)-g-catechol (PEGSD)/Zn2+/(3-acrylamidophenyl) boronic acid and 2-hydroxyethyl acrylate/ionic liquids (PEGSD-Zn2+/PHA-I) via multiple bonds crosslinking including coordination, hydrogen bond, phenylborate ester bond and permanent chemical bond. The in vitro antibacterial tests prove that Zn2+ incorporated polycationic hydrogel possesses excellent antibacterial property for MRSA and E. coli. Besides, the hydrogel has good cytocompatibility and antioxidation. The healing effect of hydrogel is demonstrated on the MRSA-infected mouse neck skin wound model, showing improved wound closing rate, collagen deposits and thickness of granulation tissue, due to the reduced inflammation and enhanced angiogenesis. In conclusion, the PEGSD-Zn2+/PHA-I hydrogel effectively promotes MRSA-infected motion wound healing and presents a new motion wound dressing design strategy of combining multiple biological activities and multiple bonds crosslinked network.