A new hydrogel to promote healing of bacteria infected wounds: Enzyme-like catalytic activity based on MnO2 nanocrytal

• Published in: Chemical engineering journal (Lausanne, Switzerland : 1996) Switzerland : 1996), 2023-08, Vol.470, p.143986, Article 143986
• Main Authors: Chen, Guoguang, Yan, Shiyu, Ouyang, Chengcheng, Qiu, Lirong, Liu, Jia, Ren, Lili
• Format: Article
• Language: English
• ISSN: 1385-8947
• DOI: 10.1016/j.cej.2023.143986

Schematic diagram of the screening of different crystalline types of MnO2 and its functionalized hydrogel for bacterial infected wound. [Display omitted] •The enzyme-like compounds MnO2 with different crystal structures were synthesized.•The catalytic activity of different crystalline MnO2 were studied, among which β-MnO2 had the best catalytic activity.•A β-MnO2 functional hydrogel (GelTA@MRS) was prepared and its catalytic performance and antibacterial activity were studied.•GelTA@MRS has better biocompatibility, and could quickly promote healing of wound infection. Manganese dioxide (MnO2) nanocrystal, a kind of nanomaterial with excellent enzyme-like catalytic properties, have been widely used in chemical, biological and pharmaceutical fields. It is composed of unique octahedral units that form a variety of tunnels and layered structures, which also lead to the emergence of different crystal forms and properties. In this study, different crystalline types of MnO2 were synthesized by different methods, and different substrates were used to study MnO2 catalytic ability of H2O2. β- MnO2 nanocrystal had nearly 50% oxygen, among which adsorbed oxygen accounted for nearly 65%, so it exhibited the best catalytic performance and could promote oxidation catalytic reaction well. Furthermore, a functional MnO2 hydrogel was prepared using β-MnO2 as antibacterial agent and natural gelatin hydrogel as carrier. The antibacterial performance of the new hydrogel was further studied, and the survival rate of different species of bacteria was