Complete degradation of propranolol by a water falling film non-thermal plasma reactor: The effects of input power and plasma gases on transformation pathway

• Published in: Chemical engineering journal (Lausanne, Switzerland : 1996) Switzerland : 1996), 2024-10, Vol.497, p.154685, Article 154685
• Main Authors: Savić, Slađana D., Kovačević, Vesna V., Stanković, Dalibor M., Sretenović, Goran B., Vasović, Tamara D., Vlahović, Filip Ž., Dojčinović, Biljana P., Obradović, Bratislav M., Kuraica, Milorad M., Manojlović, Dragan D., Roglić, Goran M.
• Format: Article
• Language: English
• Subjects: Air; Argon; DBD; Degradation products; Gibbs free energy; Reactive species
• ISSN: 1385-8947
• DOI: 10.1016/j.cej.2024.154685

[Display omitted] •Propranolol was completely degraded by nonthermal plasma in three feed gases.•In Ar/O2 atmosphere the lowest specific energy density was achieved – 75 kJ/dm3.•H2O2 was the predominant reactive oxygen species in Ar plasma.•Hydroxyl radical had no effect on degradation in Ar/O2 mixture.•The abundance of degradation products was theoretically supported. Propranolol, a beta-blocker, is a widely used drug for cardiovascular diseases. A synthetic sample containing propranolol (PRO) solution at native pH was recirculated up to ten times through an original coaxial non-thermal plasma reactor with a water falling film. Different discharge conditions, feed gasses, and power greatly influenced the extent of PRO degradation and the abundance of degradation products. The highest degradation rates were achieved in Ar plasma, either pure or in a mixture with O2, with over 70% of PRO degraded after only two passes through the DBD reactor. The full non-thermal plasma treatment was followed by a minimal change of pH value and conductivity. On the other hand, ambient air as the feed gas resulted in 60% of PRO degradation rate after the full treatment and contributed to a major drop in pH value and an increase in the conductivity of the treated solution. The structures of 47 degradation products in all three gases were identified and the degradation pathway is proposed, supported by DFT methodology. Scavenging experiments demonstrated that hydroxyl radical was predominant when plasma was generated using ambient air and Ar, while it had a minimal effect on the degradation in the mixture of Ar and O2. The desired level of propranolol decomposition was achieved only by the adjustment of the nonchemical parameters of the treatment, such as plasma gas composition and power. These results imply that a non-thermal plasma reactor is a highly effective method for pharmaceutical wastewater treatment, with no catalysts added.