Acute effect of β amyloid on synchronized spontaneous Ca 2+ oscillations in cultured hippocampal networks

The effects of β amyloid (Aβ) on cytoplasmic Ca 2+ ([Ca 2+] c) have been studied extensively, but the current literature on this aspect is confusing. We reported that 20 μM Aβ 25–35 significantly inhibited the synchronized spontaneous cytoplasmic Ca 2+ transients immediately after application, where...

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Bibliographic Details
Published in:Cell biology international 2006-09, Vol.30 (9), p.733-740
Main Authors: Rui, Yanfang, Li, Ruxin, Liu, Yifu, Zhu, Shaoqing, Yu, Xinzhu, Sheng, Zhonghua, Xie, Zuoping
Format: Article
Language:English
Subjects:
Ca 2+ imaging
Ca 2+ oscillation
Ca 2+ transient
β Amyloid
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Summary:The effects of β amyloid (Aβ) on cytoplasmic Ca 2+ ([Ca 2+] c) have been studied extensively, but the current literature on this aspect is confusing. We reported that 20 μM Aβ 25–35 significantly inhibited the synchronized spontaneous cytoplasmic Ca 2+ transients immediately after application, whereas it had little effect on the baseline [Ca 2+] c concentration in neurons. Aβ 1–42 had a similar effect on the Ca 2+ transients as Aβ 25–35, while it increased baseline [Ca 2+] c concentration gradually. However, Aβ 1–40 had little effect on either Ca 2+ transients or baseline [Ca 2+] c. Such differential effects of Aβ on Ca 2+ signals might explain, at least partially, the confusing observations from the previous studies and provide important therapeutic implications for preventing or reversing early neuron damage in Alzheimer's disease.
ISSN:1065-6995
1095-8355
DOI:10.1016/j.cellbi.2006.05.005