Zinc-releasing calcium phosphate cements for bone substitute materials

The goal of the present study was to develop zinc-doped calcium phosphate bone cements (CPCs-Zn) for functionalized bone grafts applications. An aqueous co-precipitation process for synthesis of β-tricalcium phosphate (β-TCP) powder samples with Zn addition ranging from 0wt% up to 1.2wt% was propose...

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Bibliographic Details
Published in:Ceramics international 2016-11, Vol.42 (15), p.17310-17316
Main Authors: Graziani, V., Fosca, M., Egorov, A.A., Zobkov, Yu.V., Fedotov, A.Yu, Baranchikov, A.E., Ortenzi, M., Caminiti, R., Komlev, V.S., Rau, J.V.
Format: Article
Language:English
Subjects:
Antibacterial property
Bone cement
Calcium phosphate
Tricalcium phosphate
Zinc
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Summary:The goal of the present study was to develop zinc-doped calcium phosphate bone cements (CPCs-Zn) for functionalized bone grafts applications. An aqueous co-precipitation process for synthesis of β-tricalcium phosphate (β-TCP) powder samples with Zn addition ranging from 0wt% up to 1.2wt% was proposed as an alternative approach to produce CPCs-Zn, instead of mechanical mixing of powders. Real-time monitoring of structural transformations and kinetics of CPCs-Zn (Zn=0wt%, 0.6wt% and 1.2wt%) was carried out by the Energy Dispersive X-Ray Diffraction technique. The microstructure development in CPCs-Zn was investigated by Scanning Electron Microscopy. Zn-ion release from CPC-Zn 0.6wt% and CPC-Zn 1.2wt% cements, measured by the Atomic Emission Spectroscopy, corresponded to the average values of 0.30±0.01 and 0.10±0.01µg/L, respectively. The results of antibacterial tests proved the inhibitory effect towards pathogenic Escherichia coli only for the CPC-Zn 0.6wt% cement formulation.
ISSN:0272-8842
1873-3956
DOI:10.1016/j.ceramint.2016.08.027