Bioactivity and antibacterial activity against E-coli of calcium-phosphate-based glasses: Effect of silver content and crystallinity

• Published in: Ceramics international 2017-11, Vol.43 (16), p.13800-13809
• Main Authors: Capela, M.N., Tobaldi, D.M., Oliveira, C., Pereira, A., Duarte, A.S., Seabra, M.P., Fernandes, M.H.V.
• Format: Article
• Language: English
• Subjects: Antibacterial; Bioactive; Glass; Glass-ceramic; Silver
• ISSN: 0272-8842; 1873-3956
• DOI: 10.1016/j.ceramint.2017.07.100

In this work we developed improved bioactive glasses and glass-ceramics for biomedical applications, investigating their in vitro bioactivity, biocompatibility and antibacterial properties against E-Coli. A melt-quenched bioactive glass of the SiO2-CaO-P2O5-MgO system was modified with the addition of 1 and 2mol% Ag2O and the 1mol% Ag2O-containing glasses were then heat treated to produce glass-ceramics. Surface modifications after soaking in SBF and ionic concentration changes showed that addition of silver and crystallization did not affect bioactivity although crystalline phases promoted a decrease in the degradation rate. Biocompatibility of all Ag-containing glasses and glass-ceramics was confirmed for certain samples concentrations. The antibacterial activity of the glasses against E-Coli was generally improved with decreasing particle size or increasing Ag2O. The Ag-containing glass-ceramics with higher content of crystalline phase appears as a promising biocompatible biocidal material with potential applications in bone-related diseases.