Synthesis and characterization of Sr2+ and Gd3+ doped magnetite nanoparticles for magnetic hyperthermia and drug delivery application

Commendable efforts have been gingered towards the fight against cancer. Nevertheless, it remains a major public health concern due to its predominant cause of death globally. Given this, we synthesized two different nanoparticles, Sr2+ and Gd3+ doped magnetite for magnetic hyperthermia and drug del...

Full description

Saved in:
Bibliographic Details
Published in:Ceramics international 2023-06, Vol.49 (12), p.19851-19860
Main Authors: Olusegun, Sunday J., Osial, Magdalena, Majkowska-Pilip, Agnieszka, Żelechowska-Matysiak, Kinga, Nieciecka, Dorota, Krajewski, Michal, Pękała, Marek, Krysinski, Pawel
Format: Article
Language:English
Subjects:
Drug delivery
Gadolinium
Iron oxides
Magnetic hyperthermia
Strontium
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Commendable efforts have been gingered towards the fight against cancer. Nevertheless, it remains a major public health concern due to its predominant cause of death globally. Given this, we synthesized two different nanoparticles, Sr2+ and Gd3+ doped magnetite for magnetic hyperthermia and drug delivery application. Based on the characterization, the diffractogram shows that only one phase related to magnetite with a crystallite size of 10 nm was formed. TEM images revealed nanoparticles of spherical shapes of approximately 12 nm. There is no difference in magnetic saturation of the as-received synthesized samples (Fe3O4@Sr and Fe3O4@Gd), while the BET-specific surface area of Fe3O4@Gd is 8 m2 g−1 higher than Fe3O4@Sr. The heat generation in alternating magnetic field (the magnetic hyperthermia) of Fe3O4@Sr functionalized with citric acid and loaded with 5- fluorouracil (Fe3O4@Sr@CA@5-flu) is slower than Fe3O4@Gd@CA@5-flu. The specific absorption rate (SAR) of Fe3O4@Gd@CA@5-flu, 112.0 ± 10.4 W g−1 was found to be higher than that of Fe3O4@Sr@CA@5-flu. The thermogram shows that 11% of the drug was successfully loaded on Fe3O4@Gd@CA@5-flu. The release of the antitumor drug by the synthesized nanoparticle drug carriers for ovarian cancer (SKOV-3 cells) therapy showed that more than 50% of the cancer cell’s viability was reduced after 72 h of incubation. The synthesized nanoparticles demonstrated a promising drug carrier for the treatment of SKOV-3 cells.
ISSN:0272-8842
1873-3956
DOI:10.1016/j.ceramint.2023.03.102