Multivariate analysis of five GPCR receptor classes

The family of 7-transmembrane (TM) G-protein coupled receptors (GPCRs) represent the largest family of proteins in the human genome and are the target for many of the best selling drugs used today. Here a classification analysis of five GPCR receptor classes is made based on their physico-chemical p...

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Bibliographic Details
Published in:Chemometrics and intelligent laboratory systems 2004-09, Vol.73 (1), p.95-104
Main Authors: Long, Ingrid, Andersson, Per, Seifert, Elisabeth, Lundstedt, Torbjörn
Format: Article
Language:English
Subjects:
7TM regions
GPCR
Multivariate analysis
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Summary:The family of 7-transmembrane (TM) G-protein coupled receptors (GPCRs) represent the largest family of proteins in the human genome and are the target for many of the best selling drugs used today. Here a classification analysis of five GPCR receptor classes is made based on their physico-chemical properties defined by the principal properties of the amino acids in their sequences. The studied classes all belong to the Rhodopsin family, they are the muscarinic, adrenergic, dopamine and serotonin from the amine class and melanocortin from the peptide class. The whole sequences are studied, as well as the 7TM regions separately, and the results compared. The pattern of grouping for the different classes is studied. A few examples are shown and the results are discussed.
ISSN:0169-7439
1873-3239
DOI:10.1016/j.chemolab.2003.12.008