DNA damage and cytotoxicity induced on common carp by pollutants in water from an urban reservoir. Madín reservoir, a case study

Madín Reservoir provides a substantial amount of drinking water to two municipalities close to Mexico City metropolitan area. However, it receives untreated wastewater discharges from domestic sources in the towns of Nuevo Madín and others, as well as diverse pollutants which are hauled by the Río T...

Full description

Saved in:
Bibliographic Details
Published in:Chemosphere (Oxford) 2017-10, Vol.185, p.789-797
Main Authors: Pérez-Coyotl, I., Martínez-Vieyra, C., Galar-Martínez, M., Gómez-Oliván, L.M., García-Medina, S., Islas-Flores, H., Pérez-Pasten Borja, R., Gasca-Pérez, E., Novoa-Luna, K.A., Dublán-García, O.
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents, Non-Steroidal - toxicity
Biomarkers - metabolism
Carps - metabolism
Carps - physiology
Caspase 3 - metabolism
Comet Assay
Cyprinus carpio
Cytotoxicity
DNA Damage
Environmental Monitoring
Genotoxicity
Gills - metabolism
Liver - metabolism
Madín reservoir
Mercury - metabolism
Mexico
Oxidative Stress - drug effects
Waste Water
Water Pollutants, Chemical - toxicity
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Madín Reservoir provides a substantial amount of drinking water to two municipalities close to Mexico City metropolitan area. However, it receives untreated wastewater discharges from domestic sources in the towns of Nuevo Madín and others, as well as diverse pollutants which are hauled by the Río Tlalnepantla from its upper reaches, so that the xenobiotics in the reservoir are highly diverse in terms of type and quantity. Previous studies showed that MR is contaminated with xenobiotics such as Al, Hg and Fe, as well as NSAIDs, at concentrations exceeding the limits established for aquatic life protection. These pollutants have been shown to induce oxidative stress on Cyprinus carpio and may therefore also damage the genetic material of exposed organisms, eliciting cytotoxicity as well. The present study aimed to determine the genotoxicity and cytotoxicity induced on blood, liver and gill of C. carpio by the pollutants present in MR water. Specimens were exposed to water from five sampling sites and the following biomarkers were evaluated: DNA damage by comet assay, frequency of micronuclei, apoptosis by TUNEL assay and caspase-3 activity. Significant increases relative to the control group (P 
ISSN:0045-6535
1879-1298
DOI:10.1016/j.chemosphere.2017.07.072