Effects of cyhalofop-butyl on the developmental toxicity and immunotoxicity in zebrafish (Danio rerio)

Cyhalofop-butyl is a kind of aromatic phenoxypropionic acid herbicide widely used in agriculture. However, studies on its immunotoxicity to aquatic organisms have not been reported. In this study paper, morphological, immunological, cytological, biochemical and molecular biology methods were used to...

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Bibliographic Details
Published in:Chemosphere (Oxford) 2021-01, Vol.263, p.127849, Article 127849
Main Authors: Cheng, Bo, Zou, Lufang, Zhang, Hua, Cao, Zigang, Liao, Xinjun, Shen, Tianzhu, Xiong, Guanghua, Xiao, Juhua, Liu, Huasheng, Lu, Huiqiang
Format: Article
Language:English
Subjects:
Animals
Butanes
Cyhalofop-butyl
Embryo, Nonmammalian
Embryonic Development
Immunotoxicity
JAK-STAT signaling Pathway
Nitriles
Water Pollutants, Chemical - toxicity
Zebrafish
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Summary:Cyhalofop-butyl is a kind of aromatic phenoxypropionic acid herbicide widely used in agriculture. However, studies on its immunotoxicity to aquatic organisms have not been reported. In this study paper, morphological, immunological, cytological, biochemical and molecular biology methods were used to study the effects of cyhalofop-butyl on the developmental toxicity and immunotoxicity in zebrafish. After cyhalofop-butyl exposed, the results showed that the zebrafish embryos had shorter length, yolk sac edema, significantly reduced number of immune cells, inflammatory response and immunocytes apoptosis. In addition, we found that the expression of immune-related genes and pro-apoptotic genes were up-regulated, and the JAK-STAT signaling pathway mediated the immunotoxicity induced by cyhalofop-butyl. Therefore, our results indicate that cyhalofop-butyl has developmental toxicity and immunotoxicity to zebrafish, and this study offer new contents for the effects of cyhalofop-butyl exposure on aquatic organisms. [Display omitted] •Cyhalofop-butyl induces developmental toxicity and immunotoxicity to zebrafish.•Cyhalofop-butyl induces oxidative stress and apoptosis of immune cells in zebrafish.•Jak-STAT signaling pathway is involved in cyhalofop-butyl-induced immunotoxicity in zebrafish.
ISSN:0045-6535
1879-1298
DOI:10.1016/j.chemosphere.2020.127849