Comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry combined with solid phase microextraction as a powerful tool for quantification of ethyl carbamate in fortified wines. The case study of Madeira wine

An analytical methodology based on headspace solid phase microextraction (HS-SPME) combined with comprehensive two-dimensional gas chromatography—time-of-flight mass spectrometry (GC × GC–ToFMS) was developed for the identification and quantification of the toxic contaminant ethyl carbamate (EC) dir...

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Bibliographic Details
Published in:Journal of Chromatography A 2010-05, Vol.1217 (20), p.3441-3445
Main Authors: Perestrelo, Rosa, Petronilho, Sílvia, Câmara, José S., Rocha, Sílvia M.
Format: Article
Language:English
Subjects:
Biological and medical sciences
comprehensive two-dimensional gas chromatography
Ethyl carbamate
Fermented food industries
food analysis
food contamination
Food industries
Fortified wine
fortified wines
Fundamental and applied biological sciences. Psychology
gas chromatography
GC × GC–ToFMS
HS-SPME
Madeira wine
mass spectrometry
microextraction
solid phase extraction
solid phase microextraction
time of flight mass spectrometry
Wines and vinegars
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Summary:An analytical methodology based on headspace solid phase microextraction (HS-SPME) combined with comprehensive two-dimensional gas chromatography—time-of-flight mass spectrometry (GC × GC–ToFMS) was developed for the identification and quantification of the toxic contaminant ethyl carbamate (EC) directly in fortified wines. The method performance was assessed for dry/medium dry and sweet/medium sweet model wines, and for quantification purposes, calibration plots were performed for both matrices using the ion extraction chromatography (IEC) mode ( m/ z 62). Good linearity was obtained with a regression coefficient ( r 2) higher than 0.981. A good precision was attained (R.S.D.
ISSN:0021-9673
DOI:10.1016/j.chroma.2010.03.027