Metal-organic framework grafted with melamine for the selective recognition and miniaturized solid phase extraction of aristolochic acid Ⅰ from traditional Chinese medicine

• Published in: Journal of Chromatography A 2021-06, Vol.1647, p.462155, Article 462155
• Main Authors: Shu, Hua, Chen, Guoning, Wang, Lu, Cui, Xia, Luo, Zhimin, Jing, Wanghui, Chang, Chun, Zeng, Aiguo, Zhang, Jia, Fu, Qiang
• Format: Article
• Language: English
• Subjects: Adsorption interactions; Aristolochic acid; Metal-organic framework; Mini-solid phase extraction; Traditional Chinese medicines
• ISSN: 0021-9673
• DOI: 10.1016/j.chroma.2021.462155

•Melamine was used as identification unit to provide adsorption site for AA I.•Melamine-modified MOF exhibited an excellent selectivity on aristolochic acids.•Melamine-modified MOF can efficiently recognize and enrich AA I from some TCMs. Aristolochic acid Ⅰ is a nephrotoxic compound and exist in some traditional Chinese medicines at trace level. Up to now, specific enrichment of aristolochic acid Ⅰ remains important procedure and key problem in its analysis. In this study, melamine was proposed as the recognition unit and grafted on the surface of metal-organic framework to fabricate a specific material for aristolochic acid Ⅰ. This material was prepared by using a two-step strategy and the preparation process was optimized. The physical and chemical properties were investigated using scanning electron microscopy, Fourier-transfer infrared spectroscopy, X-ray diffraction and nitrogen adsorption-desorption techniques. Adsorption properties were evaluated by binding experiments. The melamine modified material exhibited a uniform morphology, high specific surface area (460.20 m2 g−1), high adsorption capacity (25.57 mg g−1), fast mass transfer rate and excellent selectivity. Further, a specific and sensitive method was established by using this material as adsorbent of mini-solid phase extraction. The limit of detection was as low as 0.02 μg mL−1. Therefore, melamine modified metal-organic framework is an ideal adsorbent for the recognition and enrichment of aristolochic acid Ⅰ.