A Uridine Glucuronosyltransferase 2B7 Polymorphism Predicts Epirubicin Clearance and Outcomes in Early-Stage Breast Cancer

Micro-Abstract An epirubicin dose of 100 mg/m2 is well tolerated by most patients; however, a subset will experience dose-limiting toxicity. We observed statistically significant effects with a genetic variation in the enzyme uridine glucuronosyltransferase 2B7 (UGT2B7) on the clinical outcomes, epi...

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Bibliographic Details
Published in:Clinical breast cancer 2016-04, Vol.16 (2), p.139-144.e3
Main Authors: Sawyer, Michael B, Pituskin, Edith, Damaraju, Sambasivarao, Bies, Robert R, Vos, Larissa J, Prado, Carla. M.M, Kuzma, Michelle, Scarfe, Andrew G, Clemons, Mark, Tonkin, Katia, Au, Heather-Jane, Koski, Sheryl, Joy, Anil A, Smylie, Michael, King, Karen, Carandang, Diana, Damaraju, Vijaya L, Hanson, John, Cass, Carol E, Mackey, John R
Format: Article
Language:English
Subjects:
Adult
Aged
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Biomarkers, Tumor - genetics
Biomarkers, Tumor - metabolism
Breast Neoplasms - drug therapy
Breast Neoplasms - genetics
Breast Neoplasms - pathology
Cyclophosphamide - administration & dosage
Drug clearance
Epirubicin - administration & dosage
Female
Fluorouracil - administration & dosage
Follow-Up Studies
Genotype
Glucuronosyltransferase - genetics
Hematology, Oncology and Palliative Medicine
Humans
Immunoenzyme Techniques
Middle Aged
Neoplasm Grading
Neoplasm Invasiveness
Neoplasm Recurrence, Local - drug therapy
Neoplasm Recurrence, Local - genetics
Neoplasm Recurrence, Local - pathology
Neoplasm Staging
Obstetrics and Gynecology
Polymorphism, Single Nucleotide - genetics
Prognosis
Prospective Studies
Receptor, ErbB-2 - metabolism
Receptors, Estrogen - metabolism
Receptors, Progesterone - metabolism
Single nucleotide polymorphisms
SNP
Survival Rate
Toxicity
UGT2B7
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Summary:Micro-Abstract An epirubicin dose of 100 mg/m2 is well tolerated by most patients; however, a subset will experience dose-limiting toxicity. We observed statistically significant effects with a genetic variation in the enzyme uridine glucuronosyltransferase 2B7 (UGT2B7) on the clinical outcomes, epirubicin clearance, and rates of leukopenia. UGT2B7 genotyping could allow epirubicin dosing optimization to maximize efficacy and minimize toxicity.
ISSN:1526-8209
1938-0666
DOI:10.1016/j.clbc.2015.09.006