Risk-Adapted Adjuvant Chemotherapy After Concomitant Fluoropyrimidine–Radiotherapy Neoadjuvant Treatment for Patients With Resectable CT3-4 or N+ Rectal Cancer: Five-Year Disease-Free Survival Results of a Single-Center Series

Micro-Abstract Adjuvant treatment of patients with locally advanced (T3-4 or N+) rectal cancer after neoadjuvant chemoradiation and subsequent surgery is not well defined, and there is no consensus in clinical guidelines. Response to initial chemoradiation is an important prognostic factor, and a ri...

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Bibliographic Details
Published in:Clinical colorectal cancer 2016-06, Vol.15 (2), p.128-134
Main Authors: Sastre, Javier, Serrano, Juan Jose, Fernández, Cristina, Ramirez, Carmen, Ortega, Luis, García-Paredes, Beatriz, Corona, Juan, Alfonso, Rosario, Córdoba, Sofía, Díaz-Rubio, Eduardo
Format: Article
Language:English
Subjects:
Adenocarcinoma - mortality
Adenocarcinoma - therapy
Adult
Aged
Aged, 80 and over
Capecitabine
Chemoradiotherapy, Adjuvant - methods
Chemotherapy, Adjuvant - methods
Digestive System Surgical Procedures
Disease-Free Survival
Female
Fluorouracil - administration & dosage
FOLFOX/XELOX
Gastroenterology and Hepatology
Hematology, Oncology and Palliative Medicine
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Neoadjuvant chemoradiation
Neoadjuvant Therapy - methods
Proportional Hazards Models
Rectal cancer
Rectal Neoplasms - mortality
Rectal Neoplasms - therapy
Risk Factors
Risk-adapted adjuvant treatment
Treatment Outcome
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Summary:Micro-Abstract Adjuvant treatment of patients with locally advanced (T3-4 or N+) rectal cancer after neoadjuvant chemoradiation and subsequent surgery is not well defined, and there is no consensus in clinical guidelines. Response to initial chemoradiation is an important prognostic factor, and a risk-adapted adjuvant treatment based on that is feasible and deserves future research.
ISSN:1533-0028
1938-0674
DOI:10.1016/j.clcc.2015.08.001