Serum paraoxonase-1 in chronic alcoholics: Relationship with liver disease

To investigate the relationship between serum paraoxonase-1 and liver damage in chronic alcoholic patients. To assess the diagnostic accuracy of paraoxonase-1 plus standard biochemical tests in the assessment of liver damage in alcoholics. We studied 328 chronic alcoholics and 368 healthy individual...

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Published in:Clinical biochemistry 2007-06, Vol.40 (9), p.645-650
Main Authors: Marsillach, Judit, Ferré, Natàlia, Vila, Maria C., Lligoña, Anna, Mackness, Bharti, Mackness, Michael, Deulofeu, Ramon, Solá, Ricard, Parés, Albert, Pedro-Botet, Juan, Joven, Jorge, Caballeria, Joan, Camps, Jordi
Format: Article
Language:English
Subjects:
Adult
Aged
Alcoholism
Alcoholism - complications
Alcoholism - enzymology
Aryldialkylphosphatase - blood
Diagnostic accuracy
Female
Humans
Liver disease
Liver Diseases, Alcoholic - enzymology
Liver Function Tests
Male
Middle Aged
Paraoxonase-1
Prothrombin Time
Serum Albumin - analysis
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Summary:To investigate the relationship between serum paraoxonase-1 and liver damage in chronic alcoholic patients. To assess the diagnostic accuracy of paraoxonase-1 plus standard biochemical tests in the assessment of liver damage in alcoholics. We studied 328 chronic alcoholics and 368 healthy individuals. Paraoxonase-1 activity was decreased and the concentration was increased in alcoholics ( P < 0.001). The enzyme activity was correlated with albumin ( r = 0.45; P < 0.001) and prothrombin time ( r = 0.49; P < 0.001). Addition of paraoxonase-1 activity measurement to a battery of biochemical tests increased the sensitivity in differentiating between patients and controls up to 96.6% but did not improve the sensitivity in differentiating between subgroups of alcoholics. Paraoxonase-1 was related to the severity of alcoholic liver disease. Its measurement was useful in discriminating between patients and healthy subjects, but did not add any valuable information in subgroups of alcoholics.
ISSN:0009-9120
1873-2933
DOI:10.1016/j.clinbiochem.2007.01.020