Multiparametric technologies for the diagnosis of syndromic infections

Abstract The introduction of molecular diagnostics in the management of infectious diseases provides clinical microbiology with tools allowing a faster counterattack in the fight against disease-causing microbes. However, in light of the multi-and polymicrobial origin of infections and frequency of...

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Bibliographic Details
Published in:Clinical microbiology newsletter 2012-10, Vol.34 (20), p.159-168
Main Authors: Bissonnette, Luc, Ph.D, Bergeron, Michel G., O.Q., M.D., FRCPC
Format: Article
Language:English
Subjects:
Infectious Disease
Medical Education
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Summary:Abstract The introduction of molecular diagnostics in the management of infectious diseases provides clinical microbiology with tools allowing a faster counterattack in the fight against disease-causing microbes. However, in light of the multi-and polymicrobial origin of infections and frequency of antimicrobial resistance, most currently approved tests impose a limitation on clinicians, essentially due to the number of microbes a single test can identify. For many life-threatening conditions, where the balance of host-microbe interactions could dramatically shift if an inappropriate or untimely course of treatment is initiated, it would be strategically beneficial if the laboratory could detect and identify the etiology/etiologies of the infection faster and more accurately. This article reviews currently available clinical molecular microbiology tests for the diagnosis of infectious syndromes developed on multiparametric detection platforms, such as multiplex real-time PCR, molecular hybridization, nucleotide sequencing, mass spectrometry, and integrated fluidic systems.
ISSN:0196-4399
1873-4391
DOI:10.1016/j.clinmicnews.2012.09.003