Deep brain stimulation of the subthalamic nucleus affects resting EEG and visual evoked potentials in Parkinson's disease

• Published in: Clinical neurophysiology 2006-05, Vol.117 (5), p.1017-1028
• Main Authors: Jech, Robert, Růžička, Evžen, Urgošík, Dušan, Serranová, Tereza, Volfová, Markéta, Nováková, Olga, Roth, Jan, Dušek, Petr, Mečíř, Petr
• Format: Article
• Language: English
• Subjects: Aged; Analysis of Variance; Biological and medical sciences; Brain Mapping; DBS; Deep brain stimulation; Deep Brain Stimulation - methods; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Dose-Response Relationship, Radiation; EEG; Electroencephalography - radiation effects; Evoked Potentials, Visual - physiology; Evoked Potentials, Visual - radiation effects; Eye and associated structures. Visual pathways and centers. Vision; Female; Fundamental and applied biological sciences. Psychology; Humans; Male; Medical sciences; Middle Aged; Neurology; Parkinson Disease - surgery; Parkinson's disease; Reaction Time - radiation effects; STN; Subthalamic nucleus; Subthalamic Nucleus - radiation effects; VEP; Vertebrates: nervous system and sense organs
• ISSN: 1388-2457; 1872-8952
• DOI: 10.1016/j.clinph.2006.01.009

We studied changes of the EEG spectral power induced by deep brain stimulation (DBS) of the subthalamic nucleus (STN) in patients with Parkinson's disease (PD). Also analyzed were changes of visual evoked potentials (VEP) with DBS on and off. Eleven patients with advanced PD treated with bilateral DBS STN were examined after an overnight withdrawal of L-DOPA and 2 h after switching off the neurostimulators. All underwent clinical examination followed by resting EEG and VEP recordings, a procedure repeated after DBS STN was switched on. With DBS switched on, the dominant EEG frequency increased from 9.44±1.3 to 9.71±1.3 Hz ( P