Pb (P1 ) resonance at 40 Hz: Effects of high stimulus rate on auditory middle latency responses (MLRs) explored using deconvolution

• Published in: Clinical neurophysiology 2007-06, Vol.118 (6), p.1261-1273
• Main Authors: Özdamar, Özcan, Bohórquez, Jorge, Ray, Saumitra Sinha
• Format: Article
• Language: English
• Subjects: Biological and medical sciences; Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation; Electrodiagnosis. Electric activity recording; Fundamental and applied biological sciences. Psychology; Investigative techniques, diagnostic techniques (general aspects); Medical sciences; Nervous system; Neurology; Vertebrates: nervous system and sense organs
• ISSN: 1388-2457; 1872-8952
• DOI: 10.1016/j.clinph.2007.02.016

Abstract Objective In this study, the effects of high stimulus rate on middle latency response (MLR) components Pa and Pb (P1 or P50) were studied using high rate clicks in normal hearing awake subjects were investigated. Methods Five jittered click sequences at different mean rates (24.4, 39.1, 58.6, 78.1, 97.7 Hz) were presented to 10 subjects. Overlapping MLRs were deconvolved using the frequency domain continuous loop averaging deconvolution (CLAD) [Özdamar Ö., Bohórquez, J., Signal to noise ratio and frequency analysis of continuous loop averaging deconvolution (CLAD) of overlapping evoked potentials. J. Acoust. Soc. Am., 119:429–438, 2006]. In addition conventional auditory transient MLRs at 4.88 Hz were obtained using conventional averaging. Results Pa amplitude, latency and waveshape remained fairly constant up to 78.1 Hz. Pb component, however, showed a variable waveshape with latencies covering a wide range (50–70 ms) and Nb –Pb amplitudes increasing at 39.1 and 58.6 Hz and decreasing at other rates. Conclusions Recordings show that both Pa and Pb MLR components can be consistently recorded at all rates up to 100 Hz. Pb amplitude shows an increase at around 40 Hz showing a resonance at that frequency. Significance The dramatic increase of the Pb component at around 40 Hz may account for the high amplitude of the 40 Hz ASSR.