P 204. Additive effect of repetitive transcranial magnetic stimulation and anticonvulants

• Published in: Clinical neurophysiology 2013-10, Vol.124 (10), p.e161-e161
• Main Authors: Kistsen, V, Evstigneev, V, Dubovik, B
• Format: Article
• Language: English
• Subjects: Neurology
• ISSN: 1388-2457; 1872-8952
• DOI: 10.1016/j.clinph.2013.04.281

Objective The aim of our study was to reveal of rTMS and antiepileptic drugs (AEDs) interaction effects. Methods The comparative analysis of anticonvulsive effects of rTMS combination with different AEDs (carbamazepine, valproic acid, topiramate and gabapentin) was performed. The experimental data was obtained at maximal electroshock test (MEST) on Wistar rats which took AED in minimal effective doses. RTMS with 1 Hz frequency and difference intensities was performed by circular coil (Neuro-MS, Russia) at pike concentration of AEDs time. Absence of maximal tonic hind limb extension (MTHLE) and all seizure phases durations were estimated. Results of combined therapy groups were conferred with monotherapy (AED or rTMS only) and control group ( n = 10 in each group). Results RTMS has additive effect concerning MTHLE absence when assign with carbamazepine in ED40 in 90% ( p = 0.01) and topiramate in ED30 in 80% animals ( p = 0.035). Tonic phase duration significant shorten practically in all rTMS + AEDs groups, particular with topiramate ( p = 0.002), but had not potentiating effect with gabapentin ( p = 0.12). RTMS shortened phase of clonic seizures with body turning-over reflex loss and total seizure duration for all AEDs ( p < 0.05). Period after turning-over reflex recovery corrected by rTMS in carbamazepine group only ( p = 0.04). Limbs “pedaling” phenomenon reduced in “rTMS + carbamazepine” ( p = 0.01) and “rTMS + valproic acid” ( p = 0.001) groups. Conclusions Thereby, rTMS has an additive effect with AEDs. Magnetic stimulation causes the most important anticonvulsive effects when arrange with carbamazepine and topiramate. Results of this study can to be a reason to include low-frequency rTMS in epilepsy treatment with low AEDs dose what can deliver patients from negative side effects.