Abnormal corticospinal tract function and motor cortex excitability in non-ataxic SCA2 mutation carriers: a TMS study

Highlights • TMS markers of corticospinal tract integrity are altered in non-ataxic SCA2 mutation carriers. • Motor thresholds are elevated, and cortical silent periods and CMCT are prolonged. • CMCT correlates directly with CAG repeat length, and inversely with predicted time to ataxia onset.

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Bibliographic Details
Published in:Clinical neurophysiology 2016-08, Vol.127 (8), p.2713-2719
Main Authors: Velázquez-Pérez, Luis, Rodríguez-Labrada, Roberto, Torres-Vega, Reidenis, Montero, Jacqueline Medrano, Vázquez-Mojena, Yaimeé, Auburger, Georg, Ziemann, Ulf
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Ataxin-2 - genetics
Corticospinal tract
Cross-Sectional Studies
Electric Stimulation
Evoked Potentials, Motor - physiology
Female
Heterozygote
Humans
Male
Middle Aged
Motor cortex
Motor Cortex - physiopathology
Motor evoked potentials
Mutation
Neural Conduction - physiology
Neurology
Prodromal disease stage
Pyramidal Tracts - physiopathology
Spinocerebellar ataxia type 2
Transcranial Magnetic Stimulation
Young Adult
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Description
Summary:Highlights • TMS markers of corticospinal tract integrity are altered in non-ataxic SCA2 mutation carriers. • Motor thresholds are elevated, and cortical silent periods and CMCT are prolonged. • CMCT correlates directly with CAG repeat length, and inversely with predicted time to ataxia onset.
ISSN:1388-2457
1872-8952
DOI:10.1016/j.clinph.2016.05.003