P241 Insula connectivity during wakefulness and sleep studied through single pulse electrical stimulation during seeg recordings

We aim to study the connections of the posterior insula (pI) and anterior insula (aI) through cortico-cortical evoked potentials (CCEP) by single pulse electrical stimulation (SPES). We performed SPES stimulation protocol in a group of 8 refractory epilepsy patients presurgically explored with intra...

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Bibliographic Details
Published in:Clinical neurophysiology 2017-09, Vol.128 (9), p.e255-e256
Main Authors: Arbune, Anca Adriana, Mindruta, Ioana, Maliia, Mihai, Popa, Irina, Donos, Cristian, Ene, Sabina, Ciurea, Jean, Barborica, Andrei
Format: Article
Language:English
Subjects:
Anterior insula
CCEP
Epilepsy
Insula
Language
Posterior insula
Sleep
SPES
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Summary:We aim to study the connections of the posterior insula (pI) and anterior insula (aI) through cortico-cortical evoked potentials (CCEP) by single pulse electrical stimulation (SPES). We performed SPES stimulation protocol in a group of 8 refractory epilepsy patients presurgically explored with intracerebral depth electrodes, out of which 6 were operated on and are currently seizure-free. We selected the early responses (ER) obtained from contacts of 24 electrodes that were included in the anterior and posterior insula, when this structure was outside the seizure onset zone (SOZ). Responses were analyzed in terms of amplitude variations during wakefulness and sleep. Effective connectivity betweeen cortical was calculated based on the measured CCEPs. The ER amplitudes by SPES stimulation in the insula during wakefulness compared to sleep showed statistically significant (p
ISSN:1388-2457
1872-8952
DOI:10.1016/j.clinph.2017.07.249