P52-S State-dependent changes in cortical reactivity: comparison between direct cortical and peripheral stimulation

Peripheral as well as direct cortical stimulations have been classically used to probe the reactivity of thalamocortical circuits across brain states, showing consistent state-dependent modifications. Here we aim at directly comparing state-dependent changes across the wake/sleep cycle of the electr...

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Published in:Clinical neurophysiology 2019-07, Vol.130 (7), p.e110-e110
Main Authors: Sarasso, Simone, Casarotto, Silvia, Fecchio, Matteo, Derchi, Camilla, Mazza, Alice, D’Ambrosio, Sasha, Viganò, Alessandro, Casali, Adenauer Girardi, Comolatti, Renzo, Comanducci, Angela, Rosanova, Mario, Massimini, Marcello, Parmigiani, Sara
Format: Article
Language:English
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Summary:Peripheral as well as direct cortical stimulations have been classically used to probe the reactivity of thalamocortical circuits across brain states, showing consistent state-dependent modifications. Here we aim at directly comparing state-dependent changes across the wake/sleep cycle of the electroencephalographic (EEG) responses to transcranial magnetic stimulation (TMS – applied over premotor and parietal areas) and to electrical median nerve stimulation (EMNS - applied at an intensity able to reproducibly elicit thumb movements) in two groups of 8 healthy individuals each. By tuning stimulation parameters, we roughly equalized the strength of brain activation elicited by TMS and EMNS during wakefulness and achieved a similar (p = 0.8) overall (0–600 ms) global mean field power (GMFP). The time-course of wakefulness GMFP significantly peaked (p 
ISSN:1388-2457
1872-8952
DOI:10.1016/j.clinph.2019.04.588