P65-S Impaired short and long latency afferent inhibition in ALS

To test the hypothesis of impaired cholinergic activity in amyotrophic lateral sclerosis (ALS), we studied the short latency (SAI) and long latency (LAI) afferent inhibition. Transcranial magnetic stimulation (TMS) was delivered to the left M1. Central motor conduction time (CMCT) and motor action p...

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Bibliographic Details
Published in:Clinical neurophysiology 2019-07, Vol.130 (7), p.e111-e111
Main Authors: Cengiz, Bülent, Fidancı, Halit, Keçeli, Yeliz Kıyak, Baltacı, Hande, Kuruoğlu, Reha
Format: Article
Language:English
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Summary:To test the hypothesis of impaired cholinergic activity in amyotrophic lateral sclerosis (ALS), we studied the short latency (SAI) and long latency (LAI) afferent inhibition. Transcranial magnetic stimulation (TMS) was delivered to the left M1. Central motor conduction time (CMCT) and motor action potential (MEP) latency were obtained. Right ulnar nerve was stimulated at the wrist preceding the TMS 21 ms for SAI and 200 ms for LAI. Twenty-one ALS patients and 17 healthy controls participated in the study. Mean CMCT (p = 0.009) and MEP latency (p = 0.02) were significantly prolonged in patients. The SAI paradigm resulted in inhibition in all healthy individuals (100%), whereas inhibition was observed in 13 out of 21 (62%) patients. Mean SAI and LAI (p 
ISSN:1388-2457
1872-8952
DOI:10.1016/j.clinph.2019.04.593