Single Nucleotide Polymorphisms in CBLB , a Regulator of T-Cell Response, Predict Radiation Pneumonitis and Outcomes After Definitive Radiotherapy for Non–Small-Cell Lung Cancer

Micro-Abstract We identified 393 patients with non–small cell lung cancer and genotyped 3 potentially functional single nucleotide polymorphisms of CBLB . We found that patients with the CBLB rs2305035 AA/AG genotypes had better clinical outcomes but were at higher risk of developing severe radiatio...

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Published in:Clinical lung cancer 2016-07, Vol.17 (4), p.253-262.e5
Main Authors: Li, Peng, Wang, Xiaohong, Liu, Zhensheng, Liu, Hongliang, Xu, Ting, Wang, HuiJuan, Gomez, Daniel R, Nguyen, Quynh-Nhu, Wang, Li-E, Teng, Yuee, Song, Yipeng, Komaki, Ritsuko, Welsh, James W, Wei, Qingyi, Liao, Zhongxing
Format: Article
Language:English
Subjects:
Adaptor Proteins, Signal Transducing - genetics
Adult
Aged
Aged, 80 and over
CBLB
Female
Genotype
Hematology, Oncology and Palliative Medicine
Humans
Immune Tolerance - genetics
Male
Middle Aged
NSCLC
Polymorphism, Single Nucleotide
Predictive Value of Tests
Prognosis
Proto-Oncogene Proteins c-cbl - genetics
Pulmonary/Respiratory
Radiation pneumonitis
Radiation Pneumonitis - diagnosis
Radiation Pneumonitis - genetics
Radiation Pneumonitis - mortality
Radiotherapy
Survival Analysis
Treatment Outcome
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Summary:Micro-Abstract We identified 393 patients with non–small cell lung cancer and genotyped 3 potentially functional single nucleotide polymorphisms of CBLB . We found that patients with the CBLB rs2305035 AA/AG genotypes had better clinical outcomes but were at higher risk of developing severe radiation pneumonitis. The findings could assist in generating hypotheses for mechanistic studies of immunology and cancer treatment outcomes.
ISSN:1525-7304
1938-0690
DOI:10.1016/j.cllc.2015.11.008