Environmental lead toxicity and nutritional factors

Summary Environmental lead toxicity is an old but persistent public health problem throughout the world and children are more susceptible to lead than adults because of their hand to mouth activity, increased respiratory rates and higher gastrointestinal absorption per unit body weight. In the last...

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Bibliographic Details
Published in:Clinical nutrition (Edinburgh, Scotland) Scotland), 2007-08, Vol.26 (4), p.400-408
Main Authors: Ahamed, Maqusood, Siddiqui, Mohd. Kaleem Javed
Format: Article
Language:English
Subjects:
Biological and medical sciences
Chelating agents
Child
Child, Preschool
Environment. Living conditions
Environmental Exposure - adverse effects
Essential elements
Food-Drug Interactions
Gastroenterology and Hepatology
Humans
Lead exposure
Lead Poisoning - blood
Lead Poisoning - etiology
Medical sciences
Metabolic diseases
Nutritional factors
Nutritional Status
Public Health
Public health. Hygiene
Public health. Hygiene-occupational medicine
Trace Elements - administration & dosage
Treatment
Vitamins
Vitamins - administration & dosage
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Summary:Summary Environmental lead toxicity is an old but persistent public health problem throughout the world and children are more susceptible to lead than adults because of their hand to mouth activity, increased respiratory rates and higher gastrointestinal absorption per unit body weight. In the last decade children's blood lead levels have fallen significantly in a number of countries. Despite this reduction, childhood lead toxicity continues to be a major public health problem for certain at-risk groups of children, and concern remains over the effects of lead on intellectual development. The currently approved clinical intervention method is to give chelating agents, which bind and removed lead from lead burdened tissues. Studies indicate, however, that there is a lack of safety and efficacy when conventional chelating agents are used. Several studies are underway to determine the beneficial effect of nutrients supplementation following exposure to lead. Data suggest that nutrients may play an important role in abating some toxic effects of lead. To explain the importance of using exogenous nutrients in treating environmental lead toxicity the following topics are addressed: (i) different sources of lead exposure/current blood lead levels and (ii) protective effects of nutrients supplementation (some essential elements and vitamins) in lead toxicity.
ISSN:0261-5614
1532-1983
DOI:10.1016/j.clnu.2007.03.010