Peri-operative corticosteroids to prevent iatrogenic adrenal insufficiency: are the doses used too high?

Background Optimal peri‐operative corticosteroid dosing to avoid excess or deficiency for patients taking chronic prednisone (c‐PRED) is unknown. Methods In a randomized double‐blind trial, traditional doses of IV hydrocortisone (HC) were compared to lower doses matched to patients' c‐PRED dose...

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Bibliographic Details
Published in:Clinical pharmacology and therapeutics 2004-02, Vol.75 (2), p.P76-P76
Main Authors: Zarnke, K. B., Dresser, G., Moor, R., Colquhoun, P., Taylor, B., Larocque, B., Sue‐A‐Quan, G., Gilbert, K., Bycraft, C., Martin, J., Badner, N., McDonald, C., Paul, T., Mahon, J. L.
Format: Article
Language:English
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Summary:Background Optimal peri‐operative corticosteroid dosing to avoid excess or deficiency for patients taking chronic prednisone (c‐PRED) is unknown. Methods In a randomized double‐blind trial, traditional doses of IV hydrocortisone (HC) were compared to lower doses matched to patients' c‐PRED dose. Patients taking ≥G5mg c‐PRED for ≥G2 wks within
ISSN:0009-9236
1532-6535
DOI:10.1016/j.clpt.2003.11.287