Lopinavir/ritonavir reduces lamotrigine plasma concentrations in healthy subjects

Background Limited data are available about the effect of lopinavir and low‐dose ritonavir on glucuronidation. Lamotrigine undergoes glucuronidation. We studied the effect of lopinavir/ritonavir on the pharmacokinetics of lamotrigine and vice versa. Methods Twenty‐four healthy subjects received 50 m...

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Bibliographic Details
Published in:Clinical pharmacology and therapeutics 2006-08, Vol.80 (2), p.159-168
Main Authors: Lee, Manon J., Dawood, Lara, Hofstede, Hadewych J.M., Graaff‐Teulen, Marga J.A., Ewijk‐Beneken Kolmer, Eleonora W.J., Caliskan‐Yassen, Nurcan, Koopmans, Peter P., Burger, David M.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Anti-HIV Agents - adverse effects
Anticonvulsants - blood
Anticonvulsants - pharmacokinetics
Area Under Curve
Biological and medical sciences
Biotransformation
Contraceptives, Oral, Hormonal - adverse effects
Depression, Chemical
Double-Blind Method
Drug Interactions
Female
Glucuronides - blood
Humans
Lopinavir
Male
Medical sciences
Middle Aged
Patient Compliance
Pharmacology. Drug treatments
Pyrimidinones - adverse effects
Sex Characteristics
Triazines - blood
Triazines - pharmacokinetics
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Summary:Background Limited data are available about the effect of lopinavir and low‐dose ritonavir on glucuronidation. Lamotrigine undergoes glucuronidation. We studied the effect of lopinavir/ritonavir on the pharmacokinetics of lamotrigine and vice versa. Methods Twenty‐four healthy subjects received 50 mg lamotrigine once daily on days 1 and 2 and 100 mg twice daily on day 3 through day 23. Lopinavir (400 mg twice daily)/ritonavir (100 mg twice daily) was added on day 11. Depending on the decrease in lamotrigine trough level between days 10 and 20, either the study was stopped (
ISSN:0009-9236
1532-6535
DOI:10.1016/j.clpt.2006.04.014