Tracking plasticity of individual human brains

•Precision Functional Mapping (PFM) allows tracking of individual-level brain plasticity.•Motor and sensory disuse drive local changes in brain physiology and connectivity.•Altered brain physiology during disuse mirrors early circuit development.•Spontaneous activity pulses may help to maintain brai...

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Bibliographic Details
Published in:Current opinion in behavioral sciences 2021-08, Vol.40, p.161-168
Main Authors: Newbold, Dillan J, Dosenbach, Nico UF
Format: Article
Language:English
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Summary:•Precision Functional Mapping (PFM) allows tracking of individual-level brain plasticity.•Motor and sensory disuse drive local changes in brain physiology and connectivity.•Altered brain physiology during disuse mirrors early circuit development.•Spontaneous activity pulses may help to maintain brain organization during disuse. Understanding how behavior affects human brain organization was the original motivation behind Precision Functional Mapping (PFM), a deep phenotyping approach to human neuroimaging. Here we review the original PFM studies, as well as research investigating the impact of sensory and/or motor deprivation, or disuse, on brain function. Next, we discuss precision functional mapping of brain plasticity, focusing on experiments that tracked casting of the dominant upper extremity with daily resting-state functional MRI scans. Mechanisms that shape brain circuits during early development may persist into adulthood, helping to maintain the organization of disused circuits.
ISSN:2352-1546
2352-1554
DOI:10.1016/j.cobeha.2021.04.018