Nanobubbles for therapeutic delivery: Production, stability and current prospects

Nanobubbles (NBs) have recently garnered widespread attention for their potential use as dual diagnostic and therapeutic agents. Similar to their micron-sized relatives (microbubbles), NBs are shell-stabilized, gas-cored bubbles that in conjunction with ultrasound can be used to increase imaging con...

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Bibliographic Details
Published in:Current opinion in colloid & interface science 2021-08, Vol.54, p.101456, Article 101456
Main Authors: Batchelor, Damien V.B., Armistead, Fern J., Ingram, Nicola, Peyman, Sally A., Mclaughlan, James R., Coletta, P. Louise, Evans, Stephen D.
Format: Article
Language:English
Subjects:
Biomedical
Cancer
Chemotherapy
Drug delivery
Nanobubbles
Theranostic
Therapeutic
Triggered release
Ultrafine bubbles
Ultrasound
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Summary:Nanobubbles (NBs) have recently garnered widespread attention for their potential use as dual diagnostic and therapeutic agents. Similar to their micron-sized relatives (microbubbles), NBs are shell-stabilized, gas-cored bubbles that in conjunction with ultrasound can be used to increase imaging contrast, as well as provide a mechanism for trigger drug release and increased therapeutic delivery. In this review, we specifically focus on their development as agents to enhance drug delivery, discussing theory, characterization techniques, key formulations and prospects for translation into clinical use.
ISSN:1359-0294
1879-0399
DOI:10.1016/j.cocis.2021.101456