Celiac therapy by administration of probiotics in food products: a review

Celiac disease (CD) is a systematic immune-mediated enteropathy induced in the most genetically predisposed people by exposure to prolamin proteins. The only effective strategy for inhibiting CD is a lifelong exclusion of gluten from patient’s diet; however, adherence to a gluten-free diet (GFD) cou...

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Bibliographic Details
Published in:Current opinion in food science 2020-04, Vol.32, p.58-66
Main Authors: Norouzbeigi, Sahar, Vahid-Dastjerdi, Leily, Yekta, Reza, Sohrabvandi, Sara, Zendeboodi, Fatemeh, Mortazavian, Amir M
Format: Article
Language:English
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Summary:Celiac disease (CD) is a systematic immune-mediated enteropathy induced in the most genetically predisposed people by exposure to prolamin proteins. The only effective strategy for inhibiting CD is a lifelong exclusion of gluten from patient’s diet; however, adherence to a gluten-free diet (GFD) could be difficult for them. Because of this challenge, there is a demand for novel therapies. The utilization of probiotics in CD patient’s diets has been proposed as a novel therapy for reducing CD symptoms. Probiotic strains can suppress the gliadin toxicity through some probable mechanisms such as enzymatic hydrolysis of toxic peptides derived from gliadin. The present review describes the recent scientific researches about mechanisms of suppressing gliadin by probiotics.
ISSN:2214-7993
2214-8000
DOI:10.1016/j.cofs.2020.01.005